EDUCATION
1996-1999 Ph. D. in Organic Chemistry at Paris XI. Dissertation title: Methodology for the diastereoselective synthesis of 1,3-diols: application to the total synthesis of Dolabelide C. Supervisor : Dr J. Prunet.
1995-1996 Agrégation de Sciences Physiques – Option Chimie (4ème)
1994-1995 MS of Organic Chemistry at UPMC, Paris VI. Dissertation title: « Synthesis of a precursor for the C cycle of Taxol ». Supervisor : Dr J. Prunet.
1993 BsC s at the Ecole Normale Supérieure of Paris (ENS)
POSITIONS
2019 Research Director at CNRS (DR 2) at the ENS Paris – UMR 7203
2016 Research Director at CNRS (DR 2) at the ENS Paris – UMR 8640
2012 Researcher at CNRS (CR 1) at the ENS Paris – UMR 8640
2012 Professor (PCC) at the Ecole Polytechnique
2010 Researcher at CNRS (CR 1) at the Ecole Polytechnique -UMR 7652
2006 Habilitation à diriger des recherches (HDR, Paris XI)
1999-2010 Assistant Professor at the ENSTA.
RESEARCH INTERESTS
Mechanistic studies, Physical Organic Chemistry
Organometallic Chemistry (Pd, Ni, Cu…)
Isocyanide-based Multicomponent Reactions
Electrosynthesis
PUBLICATIONS
2023
135. Assessing the extent of potential inversion by cyclic voltammetry: theory, pitfalls, and application to a nickel complex with redox-active iminosemiquinone ligands. Hessin, C.; Schleinitz, J.; Le Breton, N.; Choua, S.; Grimaud, L.; Fourmond, V.; Desage-El Murr, M.; Leger, C. Inorg. Chem. 2023, accepted.
134. A Mn(OAc)3 triggered formation of cyclopropanes from Ugi adducts. El Kaim, L.; Grimaud, L.; Vitale, M.; Cheibas, C.; Vieu, E.; Casaretto, N. Synlett 2023, accepted.
2022
133. Copper-Catalyzed Homocoupling of Boronic Acids: A focus on B-to-Cu and Cu-to-Cu Transmetalations. Salamé, A.; Rio, J.; Ciofini, I.; Perrin, L.; Grimaud, L.*; Payard, P. -A. Molecules 2022, 27(21), 7517-7531. doi: 10.3390/molecules27217517
132. Machine Learning Yield Prediction from NiCOlit, a Small-Size Literature Dataset of Nickel Catalyzed C-O Couplings. Schleinitz, J.; Langevin, M.; Smail, Y.; Wehnert, B.; Grimaud, L.;* Vuilleumier, R. J. Am. Chem. Soc., 2022, 144, 14722–14730. DOI 10.1021/jacs.2c05302
131. From FFN dual probe screening to ITO microdevice for exocytosis monitoring: electrochemical and fluorescence requirements. Pandard, J.; Pan, N.; Ait-Yahiatène, E.; Grimaud, L.; Lemaître, F.; Guille-Collignon, M. ChemPhysChem 2022, 9, e202200321.DOI : 10.1002/celc.202200321
130. A single bioinspired hexameric nickel catechol-alloxazine catalyst combines metal and radical mechanisms for alkene hydrosilylation. Das, A.; Schleinitz, J.; Karmazin, L.; Vincent, B.; Le Breton, N.; Guenet, A.; Choua, S.; Grimaud, L.; Desage-El Murr, M. Chem. Eur. J. 2022, 28, e202200596. DOI 10.1002/chem.202200596.
129. Electrochemical Benzylic CH Functionalization with Isocyanides. Tang, S.; Guillot, R.; Grimaud, L.*; Vitale, M. R.; Vincent, G. Org. Lett. 2022, 24, 2125-2130. DOI: 10.1021/acs.orglett.2c00364
128. Impact of the capping agent removal from Au NPs@MOF core-shell nanoparticles heterogeneous catalysts. Dai, S.; Phung Ngoc, K.; Grimaud, L.; Zhang, S.; Tissot, A.; Serre, C. J. Mat. Chem. A 2022, 10, 3201-3205.
2021
127. A hybrid bioinspired catechol-alloxazine triangular nickel complex stabilizing protons and electrons. Das, A.; Jobelius, H.; Schleinitz, J.; Gamboa-Ramírez, S.; Creste, G.; Kervern, G.; Raya, J.; Le Breton, N.; Guenet, A.; Boubegtiten, Z.; Grimaud, L.; Orio, M.; Rogez, G.; Hellwig, P.; Choua, S.; Ferlay, S.; Desage-El Murr, M. Inorg. Chem. Frontiers 2021, 8, 5286-5298. doi: 10.1039/D1QI01131F
126. Finding Adapted Quinones for Harvesting Electrons from Photosynthetic Algae Suspensions. Sayegh, A.; Perego, L. A.; Romero, M. A.; Escudero, L.; Delacotte, J.; Guille-Collignon, M.; Grimaud, L.; Bailleul, B.; Lemaître, F. ChemElectroChem 2021, 8, 2968-2978.
125. In Situ Formation of Cationic π-Allylpalladium Precatalysts in Alcoholic Solvents: Application to C–N Bond Formation. Steinsoultz, P.; Bailly, A.; Wagner, P.; Oliva, E.; Schmitt, M.; Grimaud, L.; Bihel, F. ACS Catal. 2022,1, 560–567. DOI: 10.1021/acscatal.1c04641.
124. Iron(II)-catalyzed intermolecular aziridination of alkenes employing hydroxylamine derivatives as clean nitrene sources. Kirby, G.; Grimaud, L.; Vitale, M.; Prestat, G.; Berhal, F. Green Chem. 2021, 23, 9428–9432. DOI: 10.1039/D1GC03495B.
123. Electrochemical TEMPO-Catalyzed Oxidative Ugi-Type Reaction. Pan, N.; Lee, M. X.; Bunel, L.; Grimaud, L.;* Vitale, M. ACS Organic & Inorganic Au 2021, 1, 18-22. DOI : 10.1021/acsorginorgau.1c00003
122. Copper-catalyzed transformation of alkyl nitriles to N-arylacetamide using diaryliodonium salts. Sallio, R.; Payard, P.-A.; Pakulski, P.; Diachenko, I.; Fabre, I.; Berteina-Raboin, S.; Colas, C. ; Ciofini, I.; Grimaud, L.;* Gillaizeau, I. RSC Adv., 2021, 11, 15885-15889. DOI: 10.1039/d1ra02305e.
121. Metal-Free Deoxygenation of Amine N–Oxides: Synthetic and Mechanistic Studies. Lecroq, W.; Schleinitz, J. ; Billoue, M.; Perfetto, A. ; Gaumont, A. C.; Lalevée, J.; Ciofini, I.; Grimaud, L.;* Lakhdar, S. ChemPhysChem 2021, 22, 1237-1242. DOI: 10.1002/cphc.202100108R2.
120. On the Role of Dppf Monoxide in the Transmetalation step of the Suzuki-Miyaura Coupling reaction. Payard, P.-A.; Bohn, A.; Tocqueville, D.; Jaouadi, K.; Escoude, E.; Ajig, S.; Dethoor, A.; Gontard, G.; Perego, L. A.; Vitale, M.; Ciofini, I.; Wagschal, S.; Grimaud, L.* Organometallics 2021, 40, 1120−1128. DOI: 10.1021/acs.organomet.1c00090.
119 Phenyl Silicates with Substituted Catecholate Ligands: Synthesis, Structural Studies and Reactivity. Levernier, E.; Jaouadi, K.; Zhang, H. -R.; Corcé, V.; Bernard, A.; Gontard, G.; Troufflard, C.; Grimaud, L.; Derat, E.; Ollivier, C.; Fensterbank, L. Chem. Eur. J. 2021, 27, 8782-8790. DOI : 10.1002/chem.202100453.
2020
118. Cyclopropyl Thioethers, New Inputs for Palladium Catalyzed Ring Opening of Cyclopropanes. Ponra, S.; Nyadanu, A.; Pan, N.; Martinand-Lurin, E.; Savy, A.; Vitale, M. R.; El Kaim, L.*; Grimaud, L.* Org. Process Res. Dev. 2020, 24, 827–834. doi: 10.1021/acs.oprd.9b00444
117. A DFT Protocol for the Prediction of 31P NMR Chemical Shifts of Phosphine Ligands in First-Row Transition Metal Complexes. Payard, P. A.; Perego, L. P.; Grimaud, L.; Ciofini, I. Organometallics 2020, 39, 17, 3121–3130. DOI: 10.1021/acs.organomet.0c00309.
116. Reversing reactivity: stereoselective desulfurative β-O-glycosylation of anomeric thiosugars with carboxylic acids under copper or cobalt catalysis. Bennai, N.; Chabrier, A.; Fatthalla, M.; Tran, C.; Yen-Pon, E. Belkadi, M.; Alami, M.;Grimaud, L.; Messaoudi, S. J. Org. Chem. 2020, 85, 8893-8909.
115. Rational Design of Lewis-Acid Catalysts for Direct Alcohol Amination, Part 2 – Titanium Triflimide as New Active Catalyst. Payard, P. A.; Finidori, C.; Guichard, L.; Cartigny,D.; Corbet, M.; Khrouz, L.; Bonneviot, L.; Wischert, R.; Grimaud, L.;* Pera-Titus, M. Eur. J. Org. Chem. 2020, 3225-3228. DOI: 10.1002/ejoc.202000413.
114. Rational Optimization of Lewis-Acid Catalysts for the Direct Amination of Alcohols, Part 1 – Activity Descriptors for Metal Triflates and Triflimides. Payard, P. A.; Finidori, C.; Guichard, L.; Cartigny,D.; Corbet, M.; Khrouz, L.; Bonneviot, L.; Wischert, R.; Grimaud, L.;* Pera-Titus, M. Eur. J. Org. Chem. 2020, 3219-3224. DOI: 10.1002/ejoc.202000229R1.
113. Iron Triflate Salts as Highly Active Catalysts for the Solvent-Free Oxidation of Cyclohexane. Payard, P. A.; Zheng, Y. -T.; Zhou, W. -J.; Khrouz, L.; Bonneviot, L.; Wischert, R.; Grimaud, L.;* Pera-Titus, M. Eur. J. O. C. 2020, 3552-3559 . DOI: 10.1002/ejoc.202000263.
112. Copper Reactivity Can Be Tuned to Catalyze the Stereoselective Synthesis of 2‑Deoxyglycosides from Glycals. Palo-Nieto, C.; Sau, A.; Jeanneret, R; Payard, P.A.; Salamé, A.; Braga Martins-Teixeira, M.; Carvalho, I.; Grimaud, L.;* Galan, M. C. Org. Lett. 2020, 22, 1991–1996. DOI: 10.1021/acs.orglett.9b04525.
111. Electrochemical TEMPO-Catalyzed Multicomponent C(sp3)-H α-Carbamoylation of Free Cyclic Secondary Amines. Pan, N.; Ling, J.; Zapata, R.; Pulicani, J.-P.; Grimaud, L.;* Vitale, M. R. Green Chem. 2019, 21, 6194-6199. DOI: 10.1039/C9GC03173A.
2019
110. A Fluorescent False Neurotransmitter as a Dual Electrofluorescent Probe for Secretory Cell Models. Pandard, J.; Pan, N.; Ebene, D. H.; Le Saux, T.; Ait-Yahiatène, E.; Liu, X.; Grimaud, L.; Buriez, O.; Labbé, E.; Lemaître, F.; Guille-Collignon, M. ChemPlusChem 2019, 84, 1578–1586. DOI: 10.1002/cplu.201900385
109. Formation and Reactivity of XPhos-Ligated Palladium(0) Complexes in Oxidative Additions. Wagschal, S.; Perego, L. A.; Simon, A.; Franco-Espejo, A.; Tocqueville, C.; Albaneze-Walker, J.; Jutand, A.; Grimaud, L.* Chem. Eur. J. 2019, 25, 6980-6987. DOI: 10.1002/chem.201900451
108. Copper-Catalysed Hydroamination of N-Allenyl Sulfonamides: The Key Role of Ancillary Coordinating Groups. Blieck, R.; Perego, L. A.; Ciofini, I.; Grimaud, L.;* Taillefer, M.; Monnier F. Synthesis 2019, 51, 1225-1234. DOI:10.1055/s-0037-1611673
107. Electroactive fluorescent false neurotransmitter FFN102 partially replaces dopamine in PC12 cell vesicles. Hu, L.; Savy, A.; Grimaud, L.; Guille-Collignon, M.; Lemaître, F.; Amatore, C.; Delacotte, J. Biophys. Chem. 2019, 245, 1-5. DOI: 10.1016/j.bpc.2018.11.001
106. From Benzofurans to Indoles: Palladium-Catalyzed Reductive Ring-Opening and Closure via β-Phenoxide Elimination. Perego, L. A.; Wagschal, S.; Grüber, R.; Fleurat-Lessard, P.; El Kaïm, L.; Grimaud, L.* Adv. Synth. Cat. 2019, 361, 151-159. DOI: 10.1002/adsc.201801225
2018
105. Metformin reveals a mitochondrial copper addiction of mesenchymal cancer cells. Müller, S.; Versini, A.; Sindikubwabo, F.; Belthier, G.; Niyomchon, S.; Pannequin, J.; Grimaud, L.; Cañeque, T.; Rodriguez R. PLOS ONE 2018, 13, e020676. DOI: 10.1371/journal.pone.0206764.
104. Direct Amination of Alcohols Catalyzed by Aluminum Triflate: an Experimental and Computational Study. Payard, P. A.; Gu, Q.; Guo, W.; Wang, Q.; Corbet, M.; Michel, C.; Sautet, P.; Grimaud, L.; Wischert, R.; Pera‐Titus, M. Chem. Eur. J. 2018, 53, 14146-14153. DOI 10.1002/chem.201801492.
103. Taming Nickel-Catalyzed Suzuki-Miyaura Coupling: a Mechanistic Focus on Boron-to-Nickel Transmetalation. Payard, P. A.; Perego, L. A.; Ciofini, I.; Grimaud, L.* ACS catal. 2018, 8, 4812–4823. DOI: 10.1021/acscatal.8b00933
101. Coupling electrochemistry and TIRF-microscopy with the fluorescent false neurotransmitter FFN102 supports the fluorescence signals during single vesicle exocytosis detection. Liu, X.; Hu, L.; Pan, N.; Grimaud, L.; Labbé, E. ; Buriez, O.; Delacotte, J.; Lemaître, F.; Guille-Collignon, M. Biophys. Chem. 2018, 235, 48-55. DOI: 10.1016/j.bpc.2018.02.004
100. Labelling of hyaluronic acids with a Re-tricarbonyl tag and percutaneous penetration into human skin studied by multimodal imaging. Henry, L.; Delsuc, N.; Laugel, C.; Lambert, F.; Sandt, C.; Hostachy, S.; Bernard, A. S.; Bertrand, H. C.; Grimaud, L.; Baillet-Guffroy, A.; Policar, C. 2018, 29,987–991. DOI: 10.1021/acs.bioconjchem.7b00825
99. Evidence for a Cooperative Mechanism Involving two Palladium(0) Centers in the Oxidative Addition of Iodoarenes. Perego, L. A.; Payard, P. A.; Haddou, B.; Ciofini, I.; Grimaud, L.* Chem. Eur. J. 2018, 24, 2192-2199. DOI: 10.1002/chem.201704899
98. TiCl4-mediated synthesis of 3,4-hetero-disubstituted isocoumarins by means of isocyanide insertion reactions. Ponra, S.; Nyadanu, A.; Maurin, S.; El Kaïm, L.; Grimaud, L.;* Vitale, M. R. Synthesis, 2018, 50, 1331-1342. DOI : 10.1055/s-0036-1591733
2017
97. Copper-Catalyzed Hydroamination of N-Allenylazoles: Access to Amino-Substituted N-Vinylazoles. Perego, L. A.; Blieck, R.; Michel, J.; Ciofini, I.; Grimaud, L.;* Taillefer, M.; Monnier, F. Adv. Synth. Cat. 2017, 359, 4388–4392. DOI: 10.1002/adsc.201700965
96. Copper-Catalyzed Hydroamination of Allenes: from Mechanistic Understanding to Methodology Development. Perego, L. A.; Blieck, R.; Groué, A.; Monnier, F.; Taillefer, M.; Ciofini, I.; Grimaud, L.*ACS Catal. 2017, 7, 4253−4264. DOI: 10.1021/acscatal.7b00911
95. Stereoselective access to trisubstituted fluorinated alkenyl thioethers. Fabre, I.; Poisson, T.; Pannecoucke, X.; Gillaizeau, I.; Ciofini, I.; Grimaud, L.* Catal. Sci. Technol. 2017, 7, 1921-1927. DOI: 10.1039/C7CY00076F
94. N-N bond formation in Ugi Processes: from nitric acid to libraries of Nitramines. Mercalli, V.; Nyadanu, A.; Cordier, C.; Tron, G. C.; Grimaud, L.;* El Kaim, L. Chem. Comm. 2017, 53, 2118-2121. DOI: 10.1039/C6CC10288C
93. A dual functional electroactive and fluorescent probe for coupled measurements of vesicular exocytosis with high spatial and temporal resolution. Liu, X.; Savy, A.; Maurin, S.; Grimaud, L.; Labbé, E.; Buriez, O.; Delacotte, J.; Amatore, C.; Lemaître, F.; Guille-Collignon, M. Angew. Chem. Int. Ed. 2017, 2366-2370. DOI: 10.1002/anie.201611145
92. Ugi-Smiles couplings of purine derivatives. Ben Abdessalem, A.; Abderrahim, R.; Dos Santos, A.; El Kaïm, L.; Grimaud, L.* Synlett 2017, 28, 691–694. DOI: 10.1055/s-0036-1588117
2016
91. Optimized Conditions for Passerini-Smiles Reactions and Applications to Benzoxazinone Syntheses. Martinand-Lurin, E.; Dos Santos, A.; Robineau,E.; Retailleau, P.; Dauban, P.; Grimaud, L.;* El Kaïm, L. Molecules 2016, 16, 1257-1270.
90. TiCl4-Mediated Preparation of Thiophtalide Derivatives via Formal Thio-Passerini Reactions. Ponra, S.; Nyadanu, A.; El Kaïm, L.; Grimaud, L.;* Vitale, M. R. Org. Lett. 2016, 18, 4060–4063.
89. Multiple Roles of Isocyanides in Imidoylative Palladium-Catalyzed Couplings – A Mechanistic Study. Perego, L. A.; Fleurat-Lessard, P.; El Kaïm, L.; Ciofini, I.; Grimaud, L.* Chem. Eur J. 2016, 22, 15491-15500.
88. Antagonist Effect of Acetates in C-N bond formation with in situ generated diazonium salts: a combined theoretical and experimental study. Fabre, I.; Perego,L. A.; Bergès,J.; Ciofini, I.; Grimaud, L.;* Taillefer, M. Eur J. Org. Chem. 2016,5887–5896.
87. Mechanistic Studies on the Pd-Catalyzed Direct C5 Arylation of Imidazoles: the Fundamental Role of the Azole as a Ligand for Pd. Perego, L. A.; Grimaud, L.;* Bellina, F. Adv. Synth. Cat. 2016, 358, 597-609.
2015
86. Hypervalent iodine-mediated synthesis of 1,2-dispirodienones: experimental and theoretical investigations. Hromjakova, T.; Retailleau, P.; Grimaud, L.; Gandon, V.; Chabaud, L.; Guillou, C. Eur. J. Org. Chem. 2015, 7494-7503.
85. Transition-Metal-Free alpha-Arylation of Enolizable Aryl Ketones and Mechanistic Evidence for a Radical Process. Pichette-Drapeau, M.; Fabre, I.; Grimaud, L.;* Ciofini, I.; Ollevier, T.; Taillefer, M. Angew. Chem. Int. Ed. 2015, 54, 10587-10591.
2014
84. Benzoxazinone synthesis via Passerini-Smiles couplings. Martinand-Lurin, E.; El Kaïm, L.; Grimaud, L.* Tetrahedron Lett. 2014,55, 5144-5146.
83. Kinetic Data on the Synergetic Role of Amines and Water in the Reduction of Phosphine Ligated-Palladium(II) to Palladium(0). Amatore, C.; El Kaïm, L.; Grimaud, L.;* Jutand, A.; Meigné, A.; Romanov, G., Eur. J.O.C 2014, 4709-4713.
82. Three Roles for Fluoride Ions in Palladium-Catalyzed Hiyama Reactions: Transmetallation of ArPdFL2 by Ar’Si(OR)3.Amatore, C.; Grimaud, L.;* Le Duc, G.; Jutand, A, Angew. Chem. Int. Ed. 2014, 53, 6982–6985.
81. Copper-Catalyzed Olefinic C-H Difluoroacetylation of Enamides. Caillot, G.; Dufour, J.; Belhomme, M. C.; Poisson, T.; Grimaud, L.; Pannecoucke, X.; Gillaizeau, I. Chem. Commun. 2014, 50, 5887-5890.
80. Nitrile synthesis through catalyzed cascades involving acid-nitrile exchange reaction. Cartigny,D.; El Kaïm, L.; Grimaud, L.;* Marion, P; Jacquot, R. Synthesis 2014, 46,1802-1806.
79. Double Smiles rearrangement of Passerini adducts towards benzoxazinones. Martinand-Lurin, E.; Dos Santos, A.; El Kaïm, L.; Grimaud, L.;* Retailleau, P. Chem. Comm. 2014,50, 2214-2217.
2013
78. Pyrrolo[2,3-d]pyrimidine synthesis through activation of N-benzyl groups by distal amides. El Kaïm, L.; Grimaud, L.;* Wagschal, S. Org. Biomol. Chem. 2013, 11, 6883-6885.
77. Substituent Effects in Ugi-Smiles Reactions. Chéron, N.; Ramozzi, R.; El Kaïm, L.; Grimaud, L.; Fleurat-Lessard, P. J. Phys. Chem. A 2013, 117, 8035−8042.
76. Lewis acid mediated fragmentation of tetrazoles towards triazoles. El Kaïm, L.; Grimaud, L.; Pravin, P. Eur. J. Org. Chem 2013, 22, 4752–4755.
75. Three-Component Metal-Free Arylation of Isocyanides. Basavanag, U. M. V.; Dos Santos, A.; El Kaïm, L.; Gamez-Montano, R.; Grimaud, L.* Angew. Chem. Int. Ed. 2013, 52, 7194-7197.
74. Metal-free aerobic oxidation of benzazole derivatives. Dos Santos, A.; El Kaïm, L. ; Grimaud, L. Org. Biomol. Chem. 2013, 11, 3282-3287.
2012
73. Oxazole synthesis from isocyanides. El Kaïm, L.; Grimaud, L.;* Pravin, P. Synlett 2012, 1361-1363.
72. Palladium catalyzed ring-opening of aminocyclopropyl Ugi adducts. Dos Santos, A.; El Kaïm, L.; Grimaud, L.;* Ramozzi, R. Synlett 2012, 438-442.
71. Four-component synthesis of indazole through Ugi-azide coupling. El Kaïm, L.; Grimaud, L.;* Purumandla, S. R. Synlett 2012, 295-297.
70. Challenging 50 years of established views on Ugi reaction: a theoretical approach. Chéron, N.; Ramozzi, R.; El Kaïm, L.; Grimaud, L.; Fleurat-Lessard, P. J. Org. Chem. 2012, 77, 1361–1366.
69. Ugi-Smiles coupling of thiouracil derivatives towards 2,4-diamino pyrimidines. Ait Sidhoum, M.; El Kaïm, L. ; Grimaud, L.* Synlett 2012, 632-636.
68. Ugi-Smiles couplings of 4-substituted pyridine derivatives: a fast access to chloroquine analogues. El Kaïm, L.; Grimaud, L.;* Pravin, P. Org. Lett. 2012, 14, 476-478.
2011
67. Xanthate Based Radical Cascade Toward Multicomponent Formation of Pyrrolopyrimidines. El Kaïm, L.; Grimaud, L.;* Pravin, P. Molecules 2011, 16,9261-9273.
66. Copper-triggered oxidative cascade as Ugi post-condensation towards pyrazoles. El Kaïm, L.; Grimaud, L.;* Ronsseray, C. Beilstein J. Chem. 2011, 7, 1310-1314.
65. Straightforward four-component access to spiroindolines. El Kaïm, L.; Grimaud, L.;* Le Goff, X. –F.; Menes-Arzate, M.; Miranda, L. D. Chem. Commun. 2011, 47, 8145-8147.
64. Evidences for the Key-Role of Hydrogen Bonds in SNAr. Chéron, N.;El Kaïm, L.; Grimaud, L.; Fleurat-Lessard, P. Chem. Eur. J. 2011, 17, 14929–14934.
63. A Density Functional Theory Study of the Nef-Isocyanide Reaction: Mechanism, Influence of Parameters and Scope. Chéron, N. ; El Kaïm, L. ; Grimaud, L. ; Fleurat-Lessard, P. J. Phys. Chem. A, 2011, 115, 10106-10112.
62. Phosphite mediated synthesis of benzimidazoles: a one-pot four-component approach from nitrophenols. El Kaïm, L.; Grimaud, L.* ; Purumandla, S. P. Eur. J. Org. Chem. 2011, 31, 6177–6180.
61.Three-component strategy towards 5-membered heterocycles from isocyanide dibromides. El Kaïm, L.; Grimaud, L.;* Pravin, P. Org. Lett. 2011, 13, 1261–1263.
60. Copper catalyzed aerobic oxidative cyclization of hydrazones to pyrazolinones. Dos Santos, A.; El Kaïm, L.; Grimaud, L.;* Ronsseray, C. Eur. J. Org. Chem. 2011, 3117–3121.
59. Allyl and Benzyl Dance under Basic Conditions. El Kaïm, L.; Grimaud, L.;* Purumandla, S. R. Synlett 2011, 1816-1820.
58. Multicomponent Synthesis of Fused Benzimidazolopiperazines. El Kaïm, L.; Grimaud, L.;* Purumandla, S. P. J. Org. Chem. 2011, 76, 4728-4733.
57. A new multicomponent reaction for the synthesis of pyridines via cycloaddition of azadienes and ketenimines. Coffinier, D.; El Kaïm, L.; Grimaud, L.;* Ruijter, E.; Orru, R. V. A. Tetrahedron Lett. 2011, 52, 3023-3025.
56. Palladium catalyzed ring opening of furans as a route to α,β-unsaturated aldehydes. El Kaïm, L.; Grimaud, L.;* Wagschal, S. Chem. Comm. 2011, 47, 1887-1889.
55. Smiles cascades towards heterocyclic scaffolds. El Kaïm, L.; Le Goff, X. -F.; Grimaud, L.;* Schiltz, A. Org. Lett. 2011, 13, 534-536.
1999-2010
54. New pyridine synthesis from hydrazone. Coffinier, D.; El Kaïm, L.; Grimaud, L.; Hadrot, S. Tetrahedron Lett. 2010,51, 6186-6188.
53. Ammonia in Ugi-Smiles couplings. Barthelon, A.; El Kaïm, L.; Gizzi, M.; Grimaud, L.* Synlett 2010,2784-2788.
52. Ugi-Smiles reactions in water. El Kaïm, L.; Grimaud, L.;* Purumandla, S. R. Tetrahedron Lett. 2010,51, 4962-4964.
51. Three-Component Fischer Indole Synthesis. El Kaïm, L.; Grimaud, L.;* Ronsseray, C. Synlett 2010, 2296-2298.
50. Nef/Perkow access to indolizine derivatives. Coffinier, D.; El Kaïm, L. ; Grimaud, L.* Synlett 2010, 2474-2476.
49. 1,2,4-Triazole synthesis via amidrazones. El Kaïm, L.; Gizzi, M.; Grimaud, L.* Synlett 2010, 1771-1774.
48. Towards new pyrrolo[2,3-d]pyrimidines scaffolds. El Kaïm, L.; Grimaud, L.;* Wagschal, S. J. Org. Chem. 2010, 75, 5343–5346.
47. New xanthate-based radical cyclization onto alkynes. El Kaïm, L.; Grimaud, L.; Miranda, L. D.; Vieu, E.; Cano-Herrera, M. A.; Perez-Labrada, K. Chem. Commun. 2010, 46, 2489 – 2491.
46. Four-component Synthesis of Imidazolinium-fused Heterocycles from Ugi-Smiles Couplings. Barthelon, A.; Legoff, X.-F.; El Kaïm, L.; Grimaud, L.* Synlett 2010, 153-157.
45. Isocyanide-based multicomponent reaction ‘without’ isocyanides. El Kaïm, L.; Grimaud, L.;* Schiltz, A. Synlett 2009, 1401-1404.
44. One-pot synthesis of oxazoles using isocyanide surrogates. El Kaïm, L.; Grimaud, L.;* Schiltz. A. Tetrahedron Lett. 2009, 50, 5235-5237.
43. Unconventional oxazole formation from isocyanides. Dos Santos, A.; El Kaïm, L.; Grimaud, L.;* Ronsseray, C. Chem. Commun. 2009, 3907-3909.
42. Isocyanide-free Ugi reactions. El Kaïm, L.; Grimaud, L.;* Schiltz, A. Org. Biomol. Chem. 2009, 7, 3024-3026.
41. Three-component Nef/Huisgen access to 1,2,4-triazoles. El Kaïm, L.; Grimaud, L.;* Wagschal, S. Synlett 2009, 1315-1317.
39. Three component Ugi-Smiles couplings of cyclic imines. El Kaïm, L.; Grimaud, L.;* Oble, J. Wagschal, S. Tetrahedron Lett. 2009, 50, 1741-1743.
38. New benzotriazole and benzimidazole scaffolds from Ugi-Smiles couplings of isocyanides. Coffinier, D.; El Kaïm, L.; Grimaud, L.* Org. Lett. 2009, 11, 995-997.
37. Thiols in Ugi- and Passerini-Smiles-type couplings. Barthelon, A.; El Kaïm, L.; Gizolme, M.; Grimaud, L.* European J. Org. Chem. 2008,35, 5974-5987.
36. New MCR-Heck-Isomerization Cascade toward Indoles. El Kaïm, L.; Gizzi, M.; Grimaud, L.* Org. Lett. 2008; 10; 3417-3419.
35. Intramolecular Kulinkovich–de Meijere reactions of various disubstituted alkenes bearing amide groups. Madelaine, C.; Ouhamou, N.; Chiaroni, A.; Vedrenne, E.; Grimaud, L.; Six, Y. Tetrahedron 2008 64, 8878-8898.
34. Ugi-Smiles access to pyrazine scaffolds. Barthelon, A.; Dos Santos, A.; El Kaïm, L.; Grimaud, L.* Tetrahedron Lett 2008, 49, 3208-3211.
33. Isocyanide addition to acylphosphonates: A formal Passerini reaction of acyl chlorides. Coffinier, D.; El Kaïm, L.; Grimaud, L.* Synlett 2008, 1133-1136
32. New Pd catalyzed aerobic oxidative cleavage and cyclization of N-aryl peptid derivatives. El Kaïm, L.; Grimaud, L.;* Ibarra, T.; Montano-Gamez, R. Chem. Comm. 2008, 11, 1350-1352.
31. From simple Ugi adducts to indanes and amidomalonates: new manganese (III) induced radical cascades. El Kaïm, L.; Grimaud, L.; Vieu, E. Org. Lett., 2007, 9, 4171-4173.
30. Ugi-Smiles access to quinoxaline derivatives. Oble, J.; El Kaïm, L.; Gizzi, M.; Grimaud, L.* Heterocycles, 2007, 73, 503-517.
29. New Ugi-Smiles-metathesis strategy towards the synthesis of pyrimido azepines. El Kaïm, L.; Gizolme, M.; Grimaud, L.;* Oble, J. J. Org. Chem. 2007, 72, 5835-5838.
28. Smiles rearrangements in Ugi and Passerini type couplings: new multicomponent accesses to O– and N‑aryl amides. El Kaïm, L.; Gizolme, M.; Grimaud, L.;* Oble, J. J. Org. Chem. 2007, 72, 4169-4180.
27. New benzothiazole and benzoxazole scaffolds from the Ugi–Smiles couplings of heterocyclic thiols. El Kaïm, L.; Gizolme, M.; Grimaud, L.;* Oble, J. Synlett 2007, 465-469.
26. New Ugi/Pictet–Spengler multicomponent formation of polycyclic diketopiperazines from isocyanides and α-keto acids. El Kaïm, L. ; Gageat, M.; Gaultier, L.; Grimaud, L. Synlett 2007, 500-502.
25. New indolizines template from the Ugi reaction. El Kaïm, L.; Gizolme, M.; Grimaud, L. Synlett 2007, 227-230.
24. O-Arylative Passerini reactions. El Kaïm, L.; Gizolme, M.; Grimaud, L.*Org. Lett. 2006, 8, 5021-5023.
23. Direct access to heterocyclic scaffolds by new multicomponent Ugi-Smiles couplings. El Kaïm, L.; Gizolme, M.; Grimaud, L.;* Oble, J. Org. Lett. 2006, 8, 4019-4021.
22. Ugi /xanthate cyclizations as a radical route to lactam scaffolds. El Kaïm, L.; Grimaud, L.; Miranda, L.; Vieu, E. Tetrahedron Lett. 2006, 47, 8259-8261.
21. New ortho-quinone methide formation: application to three component coupling of isocyanide, aldehyde and phenol. El Kaïm, L.; Grimaud, L.;* Oble, J. Organic Biomol. Chem. 2006, 4, 3410-3413.
20. Solvent-free preparation of amidophosphonates from isocyanides. El Kaïm, L.; Grimaud, L.; Hadrot, S. Tetrahedron Lett. 2006, 47, 3945-3947.
19. Phenol Ugi-Smiles systems: Strategies for the multicomponent of N-arylation of primary amines with isocyanides, aldehydes and phenols. El Kaïm, L.; Grimaud, L.;* Oble, J. Angew. Chem. Int. Ed. 2005, 44, 7961-7964.
18. Towards the Synthesis of Paulitin: New Insights into Enyne-Metathesis Mechanism. Vedrenne, E.; Royer, F.; Oble, J.; El Kaïm, L.; Grimaud, L.* Synlett 2005, 15, 2379-2381.
17. Formation of new phosphates from aldehydes by a DBU-catalysed phospha-Brook rearrangement in a polar solvent. El Kaïm, L.; Gaultier, L.; Grimaud, L.; Dos Santos, A. Synlett 2005, 15, 2335-2336.
16. Dramatic effect of boron-based Lewis acid in cross-metathesis reactions. Vedrenne, E.; Dupont, H.; Oualef, S.; El Kaïm, L.; Grimaud, L.* Synlett 2005, 4, 670-672.
15. New access to fluorinated ketoglycolic acid derivatives from trifluoropyruvamides. Colin, T.; El Kaïm, L.; Gaultier, L.; Grimaud, L.; Gatay, L. Tetrahedron Lett. 2004, 45, 5611-5613.
14. From isocyanides to trichloropyruvamides : Application to new preparation of Oxamide derivatives. El Kaïm, L.; Gaultier, L.; Grimaud, L.; Vieu, E. Tetrahedron Lett. 2004, 45, 8047-8048.
13. First Carbamates Conversion to Amides by Simple Alkyl Group Transfer from Trialkylalanes. El Kaïm, L.; Grimaud, L.; Perroux, Y.; Tirla, C. Org. Lett. 2004, 6, 381-383.
12. Condensation of ɤ-hydroxy sulfones and vinyl sulfones with aldehydes and ketones using phenyllithium as base. Rotulo-Sims, D.; Grimaud, L.;* Prunet, J. Comptes Rendus, 2004,941-944.
11. New insight into the azaenamine behavior of N-Arylhydrazones: first Aldol and improved Mannich reactions with unactivated aldehydes. El Kaïm, L.; Gautier, L.; Grimaud, L.; Michaut, V. Synlett, 2003, 12, 1844-1846.
10. The Mannich Reaction of Hydrazones: Improved Reactivity under Solvent-free Conditions. El Kaïm, L.; Gautier, L.; Grimaud, L.; M. Harwood, L.; Michaut, V. Green Chem. 2003, 5, 477-479.
9. New trimethylaluminum induced Mannich type reaction of hydrazones. El Kaïm, L.; Grimaud, L.; Perroux, Y.; Tirla, C. J. Org. Chem. 2003, 68, 8733-8735.
8. Selective Domino Ring-Closing Metathesis-Cross-Metathesis Reactions between Enynes and Electron-deficient Alkenes. Royer, F.; Vilain, C.; El Kaïm, L; Grimaud, L.* Org. Lett. 2003, 5, 2007-2009.
7. Diastereoselective Synthesis of Protected syn 1,3-Diols: Preparation of the C16-C24 Portion of Dolabelides. Grimaud, L.; de Mesmay, R.; Prunet, J. Org. Lett. 2002; 4; 419-421.
6. Amines addition to a-nitrohydrazones: application to amidrazones and triazoles formation. El Kaïm, L.; Grimaud, L.; Jana, N. K.; Mettetal, F.; Tirla, C. Tetrahedron Lett. 2002, 43, 8925-8927.
5. Studies towards the synthesis of Fipronil analogues: improved decarboxylation of a-hydrazonoacid derivatives. Ancel, J. E.; El Kaïm, L.; Gadras, A.; Grimaud, L.; Jana, N. K. Tetrahedron Lett. 2002, 43, 8319-8321.
4. Synthesis of protected syn 1,3-diols by intramolecular conjugate addition to vinyl sulfones. Grimaud, L.; Rotulo, D., Ros-Perez, R.; Guitry-Azam, L.; Prunet, J. Tetrahedron Lett. 2002, 43, 7477-7479.
3. a-Nitrohydrazones: versatile intermediates for phosphonate derivatives formation from primary nitro compounds. El Kaïm, L.; Grimaud, L.; Jana, N. K.; Tirla, C. Tetrahedron Lett. 2002, 43, 2037-2038.
2. The Mannich reaction of hydrazones amenable to solid phase synthesis: a powerful tool for heterocycle preparation. Atlan, V.; El Kaïm, L.; Grimaud, L.; Jana, N. K.; Majee, A. Synlett 2002, 2, 352-354.
1. Diastereoselective intramolecular Diels-Alder reactions towards the synthesis of a taxol C-ring precursor. Grimaud, L.; Férézou, J.-P.; Prunet, J.; Lallemand, J. –Y. Tetrahedron 1997, 53, 9253-9268.